George, Lizzie, and Ralph have been captured and confined for the world to see. George is held captive in New York City, Lizzie is imprisoned in Tokyo, and Ralph the Wolf is stored in London (references to
King Kong,
Godzilla, and
An American Werewolf in London). However, Scumlabs, who has just rebuilt their facilities in Salt Lake City, causes another accident that results in three new monsters: Boris, a rhinoceros, Curtis, a mouse, and Ruby, a lobster.
Players choose one of the three original monsters to rescue. The player
then uses the characters in the part of the world where the rescue is
held. They work as a collective to break buildings, eat people, and
destroy cars and this creates competition among players. When a player
(literally) unlocks George, Lizzie, or Ralph, then they become playable
characters. Once all the monsters are rescued, aliens begin to invade
the earth, leaving the monsters the only ones who can save the planet
they just helped partially destroy. After fending off the invasion on
Earth, the monsters rescue Myukus (a green cyclops-like
alien, Noobis is his purple pallete swap.) from Area 51 before chasing
the aliens through space, destroying the aliens' bases throughout the Solar System and eventually rampaging through their homeworld and destroying their capitol.
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